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PEA

Backed by Dr. Katie Woodley

BenefitsServing SizeFrequencyHow to Serve

BENEFITS

PEA (palmitoylethanolamide) is a naturally occurring fatty acid that helps regulate inflammation and support a balanced immune response in dogs. It works by calming overactive immune cells and supporting the endocannabinoid system, which can help reduce discomfort, irritation, and sensitivity throughout the body. This makes it beneficial for dogs dealing with chronic inflammation, skin issues, joint discomfort, and digestive imbalances. Rather than simply masking symptoms, PEA supports the body’s ability to return to a more balanced, resilient state, making it a valuable tool for long-term healing and overall wellness.


Serving Size

XS dogs
(< 10 lbs)

50-100mg

S dogs
(10 - 20 lbs)

100-200mg

M dogs
(21 - 50 lbs)

200-400mg

L dogs
(51 - 90 lbs)

400-600mg

XL dogs
(> 90 lbs)

600-800mg


FREQUENCY

Typically given 1–2 times daily, depending on the level of inflammation or discomfort. Safe for long-term use and well-tolerated in most dogs.


HOW TO SERVE

  1. Choose micronized or ultra-micronized PEA for better absorption and effectiveness.
  2. Give with food to support absorption and reduce the chance of GI upset. 
  3. Can be mixed directly into meals or given as a capsule/powder.
  4. For best results, consistently use daily rather than as-needed.


warning

IMPORTANT

Effects are often gradual. Most dogs show improvement over 2-4 weeks.


arrow_rightReferences

Britti D, Crupi R, Impellizzeri D, Gugliandolo E, Fusco R, Schievano C, Morittu VM, Evangelista M, Di Paola R, Cuzzocrea S. A novel composite formulation of palmitoylethanolamide and quercetin decreases inflammation and relieves pain in inflammatory and osteoarthritic pain models. BMC Vet Res. 2017 Aug 2;13(1):229. doi: 10.1186/s12917-017-1151-z. PMID: 28768536; PMCID: PMC5541643.

Della Rocca G, Gamba D. Chronic Pain in Dogs and Cats: Is There Place for Dietary Intervention with Micro-Palmitoylethanolamide? Animals (Basel). 2021 Mar 29;11(4):952. doi: 10.3390/ani11040952. PMID: 33805489; PMCID: PMC8065429.

Cerrato S., Brazis P., della Valle M.F., Miolo A., Puigdemont A. Effects of Palmitoylethanolamide on Immunologically Induced Histamine, PGD2 and TNFalpha Release from Canine Skin Mast Cells. Vet. Immunol. Immunopathol. 2010;133:9–15. doi: 10.1016/j.vetimm.2009.06.011.